Hormone treatment has worked for some women and men suffering from a concussion.
About TBI and endocrine dysfunction, from the VA website:
“The work at the VA Puget Sound Health Care System has demonstrated that Veterans with repetitive mTBI have a risk of developing growth hormone deficiency. Having growth hormone deficiency can lead to increased body mass index (BMI), fatigue, and symptoms of depression. These symptoms can then lead to decreases in sleep hygiene, self-esteem, psychological health, cognition, and quality of life. The Puget Sound investigators are in the process of proposing a multisite clinical trial that will investigate the efficacy of growth hormone replacement in those with TBI and growth hormone deficiency.”
The PINK Concussions Panel: The Faces of Female Brain Injury was held at the National Institutes of Health's NIH Workshop "Understanding Brain Injury in Women" on Dec 18-19, 2017.
Cheri's doctor ran blood tests and then prescribed a natural progesterone cream that she rubbed on her head twice a day. After three weeks of treatment, her migraines -- which she had for three years -- went away.
Ann Rasmusson, MD, Psychiatrist, National Center for PTSD. Her research shows that some women with PTSD (often co-occurring with a concussion) have really low levels of progesterone, and future research is needed to learn how to increase this neuroprotective and brain healing modulator. At the October 2018, PINK Concussions Summit hosted at Palo Alto VA Healthcare System. www.PINKconcussions.com.
"A study in military veterans finds that explosive blast-related concussions frequently result in hormone changes leading to problems such as sleep disturbances, fatigue, depression and poor quality of life. The research, to be presented Saturday at the Endocrine Society's 98th annual meeting in Boston, evaluated hormone levels in 41 male veterans who had been deployed to Iraq or Afghanistan.
'Some of these hormone deficiencies, which mimic some symptoms of post-traumatic stress disorder, may be treated successfully with hormone replacement if correctly diagnosed,' said the study's leader, Charles Wilkinson, Ph.D., a researcher with the Veterans Affairs (VA) Puget Sound Health Care System, Seattle." See the article in ScienceDaily.
Neuroendocrine Dysfunction in a Young Athlete With Concussion: A Case Report
11/1/2017 David M. Langelier; Gregory A. Kline; Chantel T. Debert
"An 18-year-old female ringette and basketball player presented to our sports concussion clinic 27 months after a concussion with fatigue, headache, exercise intolerance, polyuria, nocturia, and difficulties concentrating. Her history was remarkable for 4 previous concussions. Her neurologic examination was normal. Her neuroendocrine screen including thyroid function, morning cortisol, glucose, and insulin-like growth factor-1 (screening test for growth hormone deficiency) was normal. Further testing for growth hormone deficiency with an insulin hypoglycemia test revealed severe growth hormone deficiency. Urine and serum electrolytes were borderline normal, suggesting partial diabetes insipidus. Treatments with growth hormone replacement lead to complete recovery. This case highlights the importance of maintaining a high index of suspicion for neuroendocrine abnormalities in athletes with persistent symptoms after a sports concussion. Symptoms can be nonspecific and go undiagnosed for years, but appropriate recognition and treatment can restore function."